A multicenter comparative study was planned to evaluate the efficacy and tolerance of ketoprofen and diclofenac sodium in acute rheumatic and traumatic conditions. Ketoprofen is highly bound to plasma proteins, especially albumin. Recent publications include portions of the pill book guide to medication for your. In conclusion, our data indicate that a single, therapeutic dose of ketoprofen 5 mgkg sc causes significant gastrointestinal bleeding, erosions, and ulcers of. Inspire a love of reading with prime book box for kids discover delightful childrens books with prime book box, a subscription that delivers new books every 1. Ketoprofen injection contains ketoprofen as an active ingredient. The mean of injection pain during racemic ketoprofen injection was 4 2 sd 2 5 and was 2 5 2 4 during dexketoprofen injection p 0 001. It stops the production of a substance that causes pain. Preparation and quality evaluation of ketoprofen injection. Us20040116528a1 us10319,301 us31930102a us2004116528a1 us 20040116528 a1 us20040116528 a1 us 20040116528a1 us 31930102 a us31930102 a us 31930102a us 2004116528 a1 us2004116528 a1 us 2004116528a1 authority us united states prior art keywords ketoprofen composition liquid amount bicarbonate prior art date 200212 legal status the legal status is an. In horses, ketoprofen is used for musculoskeletal inflammation and pain, abdominal pain, and other inflammatory. Due to low systemic passage of ketoprofen from the gel such safety data are not relevant for local administration. Qualitative and quantitative composition of ketofen 1% active substance ketoprofen 10 mgml preservative benzyl alcohol 10 mgml for full list of excipients, see section 6.
The recommended dosage is 1 mglb 1 ml100 lbs of body weight once daily. Ketoprofen is one of the propionic acid class of nonsteroidal antiinflammatory drugs nsaid. To reduce your risk of stomach bleeding and other side effects, take this medication at the. Use of topical remedies including iontophoresis and intraarticular injections are. Ketoprofen injection is a sterile injection containing 100mgml ketoprofen injection for intramuscular or slow intravenous injection in horses and cattle. The injection pain was severe enough in 14 racemic ketoprofen patients and. Ketoprofen is an oral drug that belongs to a class of drugs called nonsteroidal antiinflammatory drugs. It has been given by injection for acute treatment and by tablet for longterm use. Administration in animals suffering from cardiac, hepatic or renal disease. The recommended dose is 3 mg ketoprofenkg bodyweight, i. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Ketoprofen injection is indicated in canadian product labeling for the.
Written by clinical pharmacology expert mark papich, this handy reference. If necessary to use ketoprofen in lactating a breastfeeding should be stopped. However, ketoprofen may occasionally cause drowsiness or dizziness in which case you should not drive or operate machinery. Although ketoprofen is labeled for intravenous use, it has been used in the muscle with occasional injection site reactions. The aim of this article is to prepare high concentration 5% of ketoprofen injection by sodium acetate as hydrotropic agent and to establish a quality evaluation method which is based on hplc to. Administration to pregnant mares, because the effects of ketoprofen on fertility. Nsaids cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Ketoprofen injection works by inhibiting the synthesis of chemicals causing pain. It is also used to relieve minor aches and pains from headaches, menstrual periods, toothaches, the common cold, fever, muscle aches, backaches, etc. Dosage with qualifiers, mild to moderate pain2550 mg po q68 h. It acts by inhibiting the bodys production of prostaglandin it was patented in 1967 and approved for medical use in 1980.
A list of us medications equivalent to ketoprofen injection is available on the drugs. In horses, intravenous dosages of ketoprofen ranging from 0. Ketoprofen oral capsule can interact with other medications, vitamins, or herbs you may be taking. It is also available in a 100 mgml injectable form. Special warnings ketoprofen should not affect your ability to drive or operate machinery. Pharmaceutical form of ketofen 1% solution for injection. Ketoprofen uses, dosage, side effects, composition. Ketoprofen v is recommended for the symptomatic treatment of fever, pain and inflammation associated with a variety of conditions including. Ketoprofen is a nonsteroidal antiinflammatory drug nsaid. Ketoprofen fda prescribing information, side effects and. Ketoprofen is a nonsteroidal antiinflammatory drug nsaid, which acts by.
As part of the trusted equine pain and sedation portfolio from zoetis, ketofen is safe and effective against equine pain and. A total of 201 of 209 patients reported pain during racemic ketoprofen injection, and 157 of 210 patients reported pain during dexketoprofen injection, respectively. Noah compendium ketofen 10% solution for injection. Treatment is administered by intravenous injection and may be repeated for up to five days. Diractin, innketoprofen european medicines agency europa eu.
The product is an fdaapproved nonnarcotic, nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. Other members of this class include ibuprofen, indomethacin, naproxen and many others. As the concentration of free and thus, biologically active ketoprofen is increased in patients with liver dysfunction and a serum albumin webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Dosage is based on your medical condition and response to treatment. Administration to pregnant mares, because the effects of ketoprofen on fertility, pregnancy or foetal health of horses have not been determined. As the concentration of free and thus, biologically active ketoprofen is increased in patients with liver dysfunction and a serum albumin ketoprofen injection is used for rheumatoid arthritis, osteoarthritis, inflammation in spinal, inflammation in backbone, swollen joints, painful menstruation and other conditions. This medicine may be used to treat osteoarthritis and rheumatoid arthritis, or painful monthly periods. Ketoprofen should be used with caution in patients with hepatic disease. Ketoprofen is an nsaid and is used for treatment of moderate pain and inflammation. Ketofen ketoprofen is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. Saunders handbook of veterinary drugs, 4th edition includes entries for 550 drugs, with convenient appendices summarizing clinically relevant information at a glance. The target organs for chronic toxicity are the gastrointestinal tract, the kidney and, to a lesser degree the liver.
Know ketoprofen uses, side effects, dosage, contraindications, benefit, interactions, purpose, drug interactions. For a listing of dosage forms and brand names by country availability, see. Ketoprofenactron generic is a nonsteroidal antiinflammatory agent nsaid, prescribed for mild to moderate pain, fever and inflammation. Ketoprofen drug information indications, dosage, side. Ketoprofen is used to relieve pain, tenderness, swelling and stiffness in conditions such as osteoarthritis and rheumatoid arthritis. How to take your medicine the usual adult dose is 1 to 2ml by injection into the muscle. Side effects gastric or renal intolerance due to inhibition of prostaglandin synthesis. Ketoprofen ketoprofen dose, indications, adverse effects. Ketoprofen extrel caps prescription and dosage sizes information for physicians and healthcare professionals. R3 see also the regulatory considerations section of this monograph. Intravenous dexketoprofen induces less injection pain than.
New to this edition are 25 new drug monographs and easy access to drug content on any mobile device. Ketoprofen is not approved in the united states for small animals, but has been. Ketoprofen injection is a sterile injection containing. Ketoprofen injection bp 2018 british pharmacopoeia. It is used to reduce swelling and to treat mild to moderate pain. Contraindications there are no known contraindications to this drug when used as directed. Ketoprofen injection is a medicine available in a number of countries worldwide. Ketoprofen injection is indicated in canadian product labeling for the alleviation of inflammation and pain associated with arthritis and traumatic musculoskeletal injuries. Ketofen may be given by the subcutaneous, intramuscular or intravenous route in the dog, and by the subcutaneous route in the cat. Studies on the local tolerance have shown that ketoprofen is well tolerated. Ketoprofen is registered for management of acute mildtomoderate pain and at a lower dosage for osteoarthritis. The most common dosage is 1 mg lb, once per day, although this dosage may be lowered.
It has a halflife in most animals of less than 2 hours, but it has a duration of action for up to 24 hours. These drugs are used for the management of mild to moderate pain, fever, and inflammation. Dosing information of ketoprofen for dogs and cats. Ketoprofen is a nonsteroidal antiinflammatory drug nsaid, which acts by blocking cyclooxygenase cox 1 and 2, an enzyme involved in the production of prostaglandins, messengers in the development of inflammation. If in scope, these drugs will include rxnorm normal forms when editing is complete. Ketoprofen works by reducing hormones that cause inflammation and pain in the. If preferred, after one injection of ketofen 1%, treatment may be followed on the next day with ketofen tablets and continued on successive days for up to four days i. An interaction is when a substance changes the way a drug works. See what others have said about ketoprofen, including the effectiveness, ease of use and side effects. The composition of the diet slightly but significantly alters the extent of absorption of ketoprofen from sustainedrelease tablets. Ketoprofen is one of the propionic acid class of nonsteroidal antiinflammatory drugs nsaid with analgesic and antipyretic effects. Uses, side effects, interactions, pictures, warnings.
Typical chromatogram for solution 5 in the related substances test and solution 4 in the assay test for ketoprofen injection as published in bp 2018. It has a halflife in most animals of less than 2 hours, but it. Onset of activity is within two hours with peak response by 12 hours. Novel and pharmaceutically elegant dosage forms of ketoprofen may be. In i and ii trimesters of pregnancy the use of ketoprofen may be in cases when the potential benefit to the mother outweighs the potential risk to the fetus. Papich dvm, ms, dacvcp, in saunders handbook of veterinary drugs fourth edition, 2016. Ketofen is a nonnarcotic, nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. Ketoprofen v is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders. Ketoprofen injection bp 2018 this chromatogram is provided for information only as an aid to analysts and is intended as guidance for the interpretation and application of bp monographs.
They work by reducing the levels of prostaglandins, chemicals produced by the body that are responsible for. Ketaflam injection ketoprofen 10%, find complete details about ketaflam injection ketoprofen 10%,nsaid from veterinary medicine supplier or manufacturermontajat pharmaceuticals co. Concurrent administration or administration of other nonsteroidal antiinflammatory drugs nsaids within 24 hours. All nsaids reduce signs of inflammation by blocking this enzyme and therefore prostaglandin production. Ketaflam injection ketoprofen 10% buy nsaid product on. Us20040116528a1 ketoprofen compositons and methods of. Pharmacology, adverse reactions, warnings and side effects. Moderate or severe pain was reported by 90 41% patients during racemic ketoprofen administration and by. Do not use in a horse if it has previously shown hypersensitivity to ketoprofen. A professional monograph about ketoprofen for veterinary use by barbara.